•         

Homologous Recombination Deficiency (HRD) Reference Products


Current Status of HRD Research

Homologous Recombination Deficiency HRD Reference Products

Homologous recombination deficiency (HRD) is a condition in which the ability of cells to repair damaged DNA through a process called homologous recombination is impaired. HRD status can be determined by analyzing the genetic makeup of tumor samples and can be used to inform treatment decisions. Poly ADP-ribose polymerase inhibitor (PARPi) is a class of drugs that has been developed for the treatment of HRD-positive cancers, especially those caused by BRCA mutations. In parallel, PARPi companion diagnostic products have been approved. There is a demand for standards for the development of IVD companion diagnostics or for the screening of companion diagnostics in clinical trials.

CD Genomics offers a wide range of HRD reference products to help you conduct research and develop new drugs for HRD-positive cancers such as ovarian and breast cancer.

See all Products

Homologous Recombination Deficiency (HRD) Reference Products Details

Our HRD rapid custom reference products are derived from paired immortalized tumor cell lines, and use WGS data to evaluate the HRD reference values of standards to meet the needs of the IVD market for reference products, in-kit negative/positive reference products, kit performance validation, routine quality control and inter-laboratory quality assessment.

Product Highlights

  • Customizable in various product forms, such as gDNA, FFPE wax blocks, ctDNA, etc.
  • Mixed samples with different ratios of tumor and normal cells are available. For customization of other HRD values, please contact us.
  • WGS data and analysis process can be used for panel accuracy validation.
  • WGS + dual sample analysis process to determine the value.
  • Wide range of HRD score distribution to simulate real samples.

Applications

  • For evaluating the stability of experiments and analysis processes.
  • Check whether each independent mutation of LOH, LST, TAI related to HRD can be accurately determined.
  • Compare WGS data with HRD panel to check Panel design.
  • Different mixing ratios of tumor and wild type can be used to determine the limit of detection for each mutation and determine the minimum tumor ratio.
  • Negative/positive reference.
* For Research Use Only. Not for use in diagnostic procedures.

Explore Our Homologous Recombination Deficiency (HRD) Reference Products:

Filter by
Cat. No. Product Name Brief Description Inquiry Basket
HRDR001 CD HRD-3-T gDNA Reference CD HRD-3-T gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR002 CD HRD-3-N gDNA Reference CD HRD-3-N gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR003 CD HRD-5-T gDNA Reference CD HRD-5-T gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR004 CD HRD-5-N gDNA Reference CD HRD-5-N gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR005 CD HRD-9-T gDNA Reference CD HRD-9-T gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR006 CD HRD-9-N gDNA Reference CD HRD-9-N gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR007 CD HRD-2-T gDNA Reference CD HRD-2-T gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR008 CD HRD-2-N gDNA Reference CD HRD-2-N gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR009 CD HRD-12-T gDNA Reference CD HRD-12-T gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
HRDR010 CD HRD-12-N gDNA Reference CD HRD-12-N gDNA Reference uses WGS data to evaluate the HRD reference value of References, which can meet the application needs of IVD enterprise reference, negative reference within the kit, kit performance verification, daily quality control and inter-room quality assessment in the IVD market.
Copyright © 2024 CD Genomics. All rights reserved.
Top
0
Inquiry Basket