Custom NGS Panel

CD-Genomics is a company with rich experience in targeted gene panel sequencing which is used to accurately detect gene variations related to diseases.

CD-Genomics provides tests for mutations in at least 68 diseases and thousands of genes. Our scientists summarize disease-related genes based on the literature related to diseases. According to the genes that the customer is interested in, we use the targeted NGS sequencing method to analyze SNP, CNV and InDels. There are two targeted sequencing methods available: amplicon-based approaches and hybridization capture-based approaches.

  • Amplicon sequencing: Specific primers are designed for PCR amplification for the target region of interest, multiplex up to 20,000+ amplicons in each reaction. Sequencing adapters are ligated or added by a second PCR amplification and the targeted DNA library is constructed. High-throughput sequencing is then performed.
  • Hybridization capture-based target enrichment: At present, the main method is hybrid capture sequencing based on liquid phase. Based on the principle of base complementary pairing, nucleic acid probes are designed for specific regions of the genome of interest. The target region hybridization enrichment of DNA/RNA library is carried out based on liquid phase environment, and the specific genetic mutation or somatic mutation in the target region are detected by high-throughput sequencing technology.
    • These panels detect variations that occur in inherited diseases, including cystic fibrosis, autism spectrum disorders, epilepsy, hearing loss research, multiple epiphyseal dysplasia, maturity-onset diabetes of the young (MODY), cardiovascular diseases, and neuromuscular disorders.

    • These panels detect variations that occur in solid tumors, including ovarian cancer, melanoma, prostate cancer, renal cancer, sarcoma, as well as cancer hotspot detection.

      • This panel contains 35 ovarian cancer-related genes for you to choose, such as BRCA1, TP53 and PTEN.

      • This panel contains 28 melanoma-related genes, including NRAS, BRAF, CDKN2A, MDM2 and other genes. You can select the gene you are interested in to build an exclusive custom panel.

      • This is an optimized gene panel containing 19 genes associated with prostate cancer. You can select the gene you are interested in to build an exclusive custom panel.

      • This is an optimized gene panel for renal cancer that contains 30 genes, such as VHL, associated with an increased risk of renal cancer.

      • This panel contains 50 sarcoma-related genes, such as ATM, ATR, ERCC2 and TP53.

      • This panel contains 50 genes related to cancer hotspot mutations, and is a collection of common mutations in many cancers.

    • These panels detect variations in haematology, including AML, CLL, core MPN, MDS/MPN overlap, myeloma, and thrombocytopenia.

      • This panel contains 42 genes associated with acute myeloid leukemia, including AML1, AML2, AML3and other related genes.

      • The panel contains 28 chronic lymphocytic leukemia-related genes for your selection, such as NOTCH1 and SF3B1.

      • This panel collects 34 core genes, such as JAK2V617F, which are associated with myeloproliferative neoplasms for you to choose.

      • This panel contains 28 genes for you to choose, including RUNX1, CEBPA and others, which are associated with myelodysplastic/myeloproliferative overlap syndromes.

      • This panel contains 59 myeloid-related genes for you to choose, such as ASXL1.

      • This panel contains 32 genes associated with thrombocytopenia for you to select.

    • These panels detect variations that occur in metabolic disorders, including lysosomal storage disorders, urea cycle disorder, fatty acid oxidation disorder, and familial hypercholesterolemia.

    • These panels detect variations in ophthalmic research, including retinitis pigmentosa, achromatopsia, cataract, glaucoma, Leber congenital amaurosis, Bardet-Biedl syndrome, ectopia lentis, vitreoretinopathy, macular degeneration, and high myopia.

    • These panels detect variations that occur in neurological disorders, including amyotrophic lateral sclerosis, spinocerebellar ataxia, dystonia, congenital myasthenic syndrome, Alzheimer's disease, and Parkinson's disease.

    • These panels detect variations in immunology research, including autoimmune, autoinflammatory syndrome, chronic granulomatous disease, complement system disorder, primary immunodeficiency, and inflammation.

    • This panel contains 156 genes related to mitochondrial disease for your selection, from mitochondrial DNA and genomic DNA.

Gene Panel Workflow

CD Genomics provides the accurate and cost-effective custom NGS panel design, optimize, sequencing and bioinformatics analysis. Our professional expert team executes quality management, following every procedure to ensure confident and unbiased results. The general workflow for custom NGS panel sequencing is outlined below.

Custom NGS Panel

Features of Custom NGS Panel

Select and submit the target genes you are interested in and we will send you a design coverage report and provide you with a quote. If you have any questions or requirements, please feel free to contact us, we will help you solve the problems and further optimize to meet your needs.

* For Research Use Only. Not for use in diagnostic procedures.

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