Drug Safety for Children

Description

Personalized medicine is particularly important for disease treatment whereby many clinically used drugs exhibit a large interindividual pharmacokinetic and pharmacodynamic variability. This variability can lead to therapeutic failure or severe toxicity. Understanding of how genetic variations influence drug disposition and action could help in disease therapy based on individual’s genetic makeup. Pharmacogenomics is the study of how variations in the human genome affect the response to medications.

Pharmacogenomics is the study of how variations in the human genome affect the response to medications.
CD Genomics provides a predesigned panel, which covers 137 pharmacogenomics related genes for children. Utilizing amplicon sequencing technology by illumina system can provide more efficient and accurate targeting for the 137 genes and mutations. This panel can help to guide for selecting appropriate drugs and dosage for individual patients, for achieving personalized medication. If necessary, you can choose genes that fit your requirements.

Diseases associated with the 137 genes, including psychiatry, neurology, rheumatology, immunology, cardiovascular, oncology, pain, infection, respiratory, gastroenterology, endocrinology, hematology.

Gene List of Drug Safety for Children Panel

ABCB1	ABCC4	ABCG2	ACE	AD0RA2A	ADCY9	ADD1	ADRA2A	ADRB1	ADRB2
AGT	AGTP1	ANKK1	APOA5	APOE	ATIC	BCHE	C11orf65	CALU	CBR3
CCHCR1	CDA	CDK4	CEP72	CES1	CETP	CFTR	CHIA	CHRNA3	CNR1
COMT	COQ2	CREB1	CRHR1	CYP1A2	CYP1B1	CYP2B6	CYP2C19	CYP2C8	CYP2C9
CYP2D6	CYP3A4	CYP3A5	CYP4F2	DPP6	DRD1	DRD2	DRD3	DYNC2H1	EPHX1
EPM2A	ERCC1	ESR1	F2	F5	FAAH	FCER2	FCGR2A	FCGR3A	FDPS

(check the Drug Safety for Children Panel Gene List for more genes)

Highlights of Drug Safety for Children Panel Sequencing Service

Target-enrichment sequencing by Illumina provides ultra-deep sequencing to target specific genomic regions with lower costs.
High coverage uniformity ensures the sequencing data more efficiency.
SNVs, indels can be detected.
Strict quality control throughout the pipeline workflow to ensure the accuracy and repeatability of the sequencing.
Fast turnaround time.

Applications of Drug Safety for Children Panel Sequencing

Precise medication guidelines
Pharmacogenomics

Service Specifications

Sample Requirements

Sample types for genome DNA from buccal swabs, blood.
Recommended amount: 2μg
Minimum amount: 1μg
Collection: DNA samples are stored in TE buffer or equivalent. Buccal swabs are collected by routine buccal swab collection.

Sequencing

Illumina PE150
Enrichment Method: Amplicon sequencing
More than 80% of bases with a ≥ Q30 quality score
Recommended sequencing depth: ≥ 500x

Bioinformatics Analysis

We provide customized bioinformatics analysis including:

Read alignment
Variant calling/Annotation

Gene Panel Workflow

CD Genomics provides the accurate and cost-effective pharmacogenomics sequencing and bioinformatics analysis. Our professional expert team executes quality management, following every procedure to ensure confident and unbiased results. The general workflow for pharmacogenomics sequencing is outlined below.

Gene Panel Workflow

For more information about the pharmacogenomics testing or need other amplification requirements, please contact us.

References:

Jing L, et al. Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy. Pharmacogenomics and Personalized Medicine, 2011. 4, 11-33.
Sarah R, et al. Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management. Pharmacogenomics and Personalized Medicine, 2010. 3, 129-143.

* For Research Use Only. Not for use in diagnostic procedures.