BRCA 1/2 Panel - CD Genomics

BRCA Panel

What are BRCA1 and BRCA2?

BRCA1 (breast cancer gene 1) and BRCA2 (breast cancer gene 2) are genes that produce proteins that help repair damaged DNA. Each person has two copies of each of these genes, and BRCA1 and BRCA2 are sometimes called tumor suppressor genes because cancer develops when certain harmful variants in them occur. People who inherit harmful variants of one of these genes have an increased risk of developing a variety of cancers, most notably breast and ovarian cancer, as well as several other cancers, including fallopian tube cancer, primary peritoneal cancer, and prostate cancer, etc. Genetic testing for these genes can confirm the diagnosis of breast and ovarian cancers and help guide treatment and management decisions.

Breast cancer is one of the most common malignancies and the leading cause of death in women worldwide. CD Genomics offers a BRCA 1/2 panel product to detect single nucleotide variations(SNVs), copy number variations(CNVs), and insertions-deletions(Indels) in the BRCA1 and BRCA2 genes.

Our BRCA 1/2 panel may contribute to the development of the era of personalized medicine, specific treatments for each disease-causing mutation in each breast cancer susceptibility gene, and sound prevention strategies. We provide the following two BRCA 1/2 panels: CDCAP BRCA 1/2 Panel (based on Hybridization capture-based target enrichment method) and CDAMP BRCA 1/2 Panel (based on Amplicon sequencing method).

You may look for our OncoRisk Panel (31 oncorisk genes) providing a comprehensive and customizable solution for targeted enrichment and sequencing of oncology-related genomic regions, enabling researchers to efficiently analyze and identify potential cancer-associated mutations and variations.

The following is a detailed description of these two products:

Features and Advantages of Our BRCA 1/2 Panel:

Specific analysis of BRCA1 and BRCA2 genes.
Designed to efficiently and accurately analyze the BRCA1 and BRCA2 genes associated with hereditary breast and ovarian cancer syndromes.
Wide range of targeting regions.
Can target all exonic regions and flanking intron sequences of BRCA1 and BRCA2.
High-performance amplicons and uniformity.
The high performance of the panel ensures reliable and consistent sequencing results for customers, even when using DNA from low-quality clinical samples or FFPE.
Strict Process for translational research labs.
Stringent quality control throughout the pipeline workflow improving the efficiency, speed and cost of hereditary breast and ovarian cancer sequencing.

Applications of Our BRCA 1/2 Panel:

Target discovery.
Drug target discovery.
Biomarker discovery.
Discovery of rare mutations and detection of low-frequency mutations.
Cancer-related mechanism research.

Specifications of Our CDCAP BRCA 1/2 Panel:

Gene	BRCA1 and BRCA2
Covered region	Whole coding sequences (CDS) of the BRCA1 and BRCA2 genes
Species	Human
Nucleic Acid Type	DNA
Variant Class	SNVs, CNVs and Indels in the BRCA1 and BRCA2 genes
Method	Hybridization capture-based target enrichment
Sample requirements	FFPE tissue, Blood
Cancer Type	Breast, ovarian, endometrial and pancreatic cancers, etc.
Sensitivity/Specificity	SNV and Indel have a sensitivity higher than 95% and a specificity higher than 99.5%
Panel content	Target enrichment reagents, library preparation reagents. If you need Beads please contact us.
Platform	Illumina, MGI, Thermo Fisher, Oxford Nanopore and PacBio
Transport Temperature	Room temperature

Specifications of Our CDAMP BRCA 1/2 Panel:

Gene	BRCA1 and BRCA2
Number of Amplicons	265
Covered region	Whole coding sequences (CDS) of the BRCA1 and BRCA2 genes
Species	Human
Nucleic Acid Type	DNA
Variant Class	SNVs, CNVs, Indels and somatic variants in the BRCA1 and BRCA2 genes
Method	Amplicon sequencing
Sample requirements	FFPE tissue, Blood
Input Quantity	1–100 ng
Cancer Type	Breast, ovarian, endometrial and pancreatic cancers, etc.
System Compatibility	iSeq 100, MiniSeq, MiSeq, and MiSeqDx
Panel content	Target enrichment reagents, library preparation reagents. If you need Beads please contact us.
Transport Temperature	Room temperature

We look forward to working with you on your innovative discoveries, so please do not hesitate to contact us.

Reference

Catana A, Apostu AP, Antemie RG. (2019) Multi gene panel testing for hereditary breast cancer - is it ready to be used? Med Pharm Rep. 92(3):220-225.

* For Research Use Only. Not for use in diagnostic procedures.