Services
Custom NGS Panel
Custom Cancer Panels CORE/50/100/400

Custom Cancer Panels CORE/50/100/400

Custom Cancer Panels CORE

Introduction

Cancer NGS panels typically target specific regions of the genome known to be associated with cancer-related genes and mutations, to study various aspects of cancer biology, including tumor profiling, identification of genetic mutations, assessment of treatment response, and exploration of potential therapeutic targets.

Our custom Cancer NGS Panels offer several library preparation, sequencing, and data analysis options for cancer research. Streamlined library prep workflows and flexible kit configurations accommodate multiple study designs.

Based on our CDCAP® and CDAMP® Target Enrichment platforms, CD Genomics offers a custom Cancer NGS Panel to evaluate DNA, RNA and entire CDS regions of over 400 genes, as well as rearranged regions in various somatic cancer-associated genes.

Our Cancer NGS Panel CORE/50/100/400 Products

Panels

Solid Tumor Panels

Enable the identification of somatic mutations, copy number alterations, and other genetic variations specific to solid tumors. Analyze these panels to understand the genetic landscape of different solid tumor types and identify potential therapeutic targets. Learn more about our Custom Solid Tumor Panels Service.
Hematology Panels

Focus on genes and regions relevant to hematological malignancies, such as leukemia, lymphoma, and myeloma. By sequencing genes associated with these diseases, you can identify specific mutations, fusion genes, and other genomic alterations that contribute to hematological cancers.
Germline Panels

Designed to include genes and regions associated with germline mutations that increase the risk of developing various types of cancer. You can identify hereditary mutations and provide genetic counseling to individuals and families at increased risk. Germline testing with custom panels can guide personalized cancer risk assessment and management strategies. Refer to our Oncorisk Panel.
Pan-Cancer Panels

Our Pancancer Panels allow to study shared molecular features and identify common pathways and genetic alterations across different cancers. Refer to our Pan-cancer Panels for more details on how to facilitate the discovery of potential therapeutic targets that may be applicable to multiple cancer types.
Immuno-Oncology Panels

Include genes associated with the immune system and immunotherapy response. Analyze these panels to investigate the interaction between tumors and the immune system, identify immune-related genetic alterations, and assess the efficacy of immunotherapies. Custom panels tailored for immuno-oncology research can aid in understanding the mechanisms of immune evasion and developing personalized immunotherapeutic approaches. Our Immune-oncology Panel investigates over 300 genes involved in tumor-immune system interactions.
Expression Pathways

Target genes and regions involved in gene expression regulation and signaling pathways. These panels can help identify biomarkers associated with specific expression pathways and guide the development of targeted therapies. Explore our RNA Cancer Panel which targets over 1300 genes for gene expression, variant, and fusion detection.

Features of Our custom Cancer NGS Panel

The panel is an NGS assay designed to detect all types of variants in over 400 genes associated with somatic cell cancers.
Our in-house targeted enrichment platform allows us to customize Panel products in different packages for different genes and enrichment needs, such as core genes, 50 genes to 400 genes.
Stringent quality control throughout the pipeline workflow ensures accurate and reproducible sequencing.
Cost and effort savings by targeting selected genes with high sensitivity and specificity.
Detects all mutation types in a single assay, including SNV, insertional deletions, large insertional deletions, CNV, rearrangements, MSI, and TMB.
Sequencing Platforms: All types of sequencing devices, Illumina, MGI, PacBio, and Oxford Nanopore.
Bioinformatics results for large deletion analysis are available through a powerful bioinformatics system.
The panel's high performance ensures reliable and consistent sequencing results for customers, even when using DNA from low-quality clinical samples or FFPE.

Custom NGS Panel Contents

CDCAP Panel Contents	Options
Library Preparation Kit	- Sonicator-based standard kit
	- Fragmentase-based standard kit
	- Enzymatic Preparation kit (Fragmentation to ER /A-tailing in a single reaction)
Hybridization Kit	- Standard hybridization kit
Hybridization Kit	- Enhanced hybridization kit
Sample Pooling Options	- Standard
Sample Pooling Options	- Multiplex
Double-Stranded cDNA Synthesis Kit
Clean Beads	CD Clean-up Beads
Polymerase Amplification Kit
CD Bioinformatics Service
Compatible Platforms	Illumina, MGI, PacBio, Nanopore

CDAMP Panel Contents	Options
Targeted Library Kit	-Targeted Library kit
Targeted Library Kit	- UMI Targeted Library kit
Primer Pools Options	- Standard Primers
Primer Pools Options	- Enhanced Primers
Clean Beads	CD Clean-up Beads
CD Bioinformatics Service
Compatible Platforms	Illumina, MGI

How Does Our Custom NGS Panel Service Work?

Custom Cancer Panels CORE

1. Initial Consultation

Understand your research goals, sample types, and the specific genetic variants or genes you wish to target.

Custom Cancer Panels CORE

2. Panel Design

Create your NGS panel and optimize the design using our extensive library of genetic content and our expertise.

Custom Cancer Panels CORE

3. Validation

Conduct rigorous validation tests to meet the highest standards of accuracy and reproducibility.

Custom Cancer Panels CORE

4. Production & Delivery

Manufacture and ship the custom panel along with comprehensive documentation and support materials.

Custom Cancer Panels CORE

5. Ongoing Support

Available to provide sequencing and bioinformatics analysis services.

Cancer NGS Panel Core/50/100/400 Gene List

Our cancer NGS panel is offered in different configurations, including the Core, 50, 100, and 400 versions, to meet different requirements and research needs, which is designed to detect variants in all types of cancers, including breast, ovarian, prostate, colorectal and other types of cancer. Customers can choose the target genes that suit your purpose from the gene list.

- Cancer NGS Panel Gene List
  - ALK APC BRAF EGFR ERBB2 KRAS MET NRAS PIK3CA RET ROS1 SMAD4 TP53 ABL1 AKT1 ALK APC ATM BRAF BRCA1 BRCA2 CDH1 CDK4 CDK6 CDKN2A CSF1R CTNNB1 DDR2 EGFR ERBB2 ERBB4 ESR1 FGFR1 FGFR2 FGFR3 GNA11 GNAQ GNAS HRAS IDH1 IDH2 JAK2 KDR KIT KRAS MAP2K1 MET MLH1 MTOR MYC MYCN NOTCH1 NRAS NTRK1 PDGFRA PIK3CA PTCH1 PTEN PTPN11 RB1 RET ROS1 SMAD4 SMO SRC STK11 TP53 AKT2 AKT3 ALK APC ARID1A ARID1B ARID2 ATM ATRX AURKA AURKB BARD1 BCL2 BLM BMPR1A BRAF BRCA1 BRCA2 BRIP1 CDH1 CDK4 CDK6 CDKN2A CHEK2 CSF1R CTNNB1 DDR2 EGFR EPCAM EPHB4 ERBB2 ERBB3 ERBB4 EZH2 FBXW7 FGFR1 FGFR2 FGFR3 FLT3 GNA11 GNAQ GNAS HNF1A HRAS IDH1 IDH2 IGF1R ITK JAK1 JAK2 JAK3 KDR KRAS MDM2 MET MLH1 MPL MRE11 MSH2 MSH6 MTOR MUTYH NBN NF1 NOTCH1 NPM1 NRAS NTRK1 PALB2 PDGFRA PDGFRB PIK3CA PIK3R1 PMS2 PRSS1 PTCH1 PTCH2 PTEN PTPN11 RAD50 RAD51C RAD51D RB1 RET ROS1 SLX4 SMAD4 SMARCB1 SMO SRC STK1 SYK TERT TOP1 TP53 VHL ABL2 ADGRA2 AKT1 AMER1 APCDD1 APEX1 APOB APOBEC1 AR ARAF ARFRP1 ARID1A ARID1B ARID2 ASXL1 ATP11B ATR ATRX AURKA AURKB AXIN1 AXL B2M B3GAT1 BACH1 BAP1 BARD1 BCL2 BCL6 BCL9 BCOR BCR BIRC2 BIRC3 BLM BRAF BRCA1 BRCA2 BRD2 BRD3 BRD4 BRIP1 BTG1 BTK BTLA CARD11 CASP5 CASP8 CBFB CBL CDK12 CDK4 CDK6 CDK8 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDX2 CEBPA CHD1 CHD2 CHD4 CHEK1 CHEK2 CHUK CIC CRBN CREBBP CRKL CRLF2 CSF1R CSF2 CSF2RA CSF2RB CSNK2A1 CTCF CTLA4 CTNNA1 CTNNB1 CUL3 CUL4A CUL4B CXCL10 CXCL11 CXCL9 CXCR3 CYLD CYP17A1 DAXX DCUN1D1 DDR2 DICER1 DIS3 DNMT1 DNMT3A DOCK2 DOT1L EGFR ELMO1 EML4 EMSY EP300 EPHA3 EPHA5 EPHA6 EPHA7 EPHB1 EPHB4 EPHB6 ERBB2 ERBB3 ERBB4 ERCC1 ERCC2 ERG ERRFI1 ESR1 ETV1 ETV4 ETV5 ETV6 EWSR1 EYA2 EZH2 FANCA FANCC FANCD2 FANCE FANCF FANCG FANCI FANCL FANCM FAS FAT1 FAT3 FBXW7 FGF1 FGF10 FGF12 FGF14 FGF19 FGF2 FGF23 FGF3 FGF4 FGF6 FGF7 FGFR1 FGFR2 FGFR3 FGFR4 FH FLCN FLT1 FLT3 FLT4 FOXA1 FOXL2 FOXO3 FOXP3 FRS2 FUBP1 GABRA6 GAS6 GATA1 GATA2 GATA3 GATA4 GATA6 GID4 GLI1 GNA11 GNA13 GNAQ GNAS GRIN2A GRM3 GSK3B GUCY1A2 GZMA GZMB GZMH H3F3A HGF HIST 1H3B HNF1A HOXA3 HRAS HSD3B1 HSP90AA1 IDH1 IDH2 IDO1 IDO2 IFITM1 IFITM3 IFNA1 IFNB1 IFNG IGF1 IGF1R IGF2 IGF2R IKBKE IKZF1 IL12A IL12B IL2 IL23A IL6 I L7R INHBA INPP4B INSR IRF2 IRF4 IRS2 ITGAE ITK JAK1 JAK2 JAK3 JUN KAT6A KDM5A KDM5C KDM6A KDR KEAP1 KEL KIT KLF4 KLHL6 KMT2A KMT2B KMT2C KNSTRN KRAS LAG3 LMO1 LRP1B LRP6 LTK LYN LZTR1 MAGI2 MAGOH MAML1 MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAP3K13 MAPK1 MAX MCL1 MDM2 MDM4 MED12 MEF2B MEN1 MET MITF MLH1 MPL MRE11 MSH2 MSH6 MTOR MUTYH MYB MYC MYCL MYCN MYD88 MYO18A NCOA3 NCOR1 NF1 NF2 NFE2L2 NFKBIA NOTCH1 NOTCH2 NOTCH3 NOTCH4 NPM1 NRAS NSD1 NSD3 NTRK1 NTRK2 NTRK3 NUP93 NUTM1 PAK3 PAK5 PALB2 PARP1 PARP2 PARP3 PARP4 PAX5 PBRM1 PDCD1 PDCD1LG2 PDGFRA PDGFRB PDK1 PGR PHF6 PHLPP2 PIK3C2B PIK3C3 PIK3CA PIK3CB PIK3CG PIK3R2 PKHD1 PLCG1 PLCG2 PMS2 PNP PNRC1 POLD1 POLE PPARG PPP2R1A PRDM1 PREX2 PRF1 PRKAR1A PRKCI PRKDC PRPF40B PRSS8 PTCH1 PTCH2 PTEN PTK2 PTPN11 PTPRC PTPRD QKI RAB35 RAC1 RAC2 RAD17 RAD50 RAD51 RAD52 RAD54L RAF1 RANBP2 RARA RB1 RBM10 REL RET RHEB RHOA RHOB RICTOR ROBO1 ROBO2 ROS1 RPA1 RPS6KB1 RPTOR RUNX1 RUNX1T1 RUNX3 SDHA SDHB SDHC SDHD SEMA3A SEMA3E SET SETBP1 SETD2 SF3A1 SF3B1 SH2B3 SKP2 SLIT2 SMAD2 SMAD3 SMAD4 SRSF2 SRSF7 STAG2 STAT3 STAT4 TERT TET2

Specimen requirements of our custom cancer screen panel

Specimen: FFPE, frozen tissue, cfDNA, RNA

Volume: 3ug DNA.

Collection: Paraffin block preferred; percentage of tumor in specimen should be >30%.

Container: Lavender-top (EDTA) tube or yellow-top (ACD) tube.

Our Gene NGS Panel Workflow

CD Genomics provides accurate and cost-effective panel sequencing and bioinformatics analysis of various somatic cancer-associated genes. Our dedicated team of experts performs quality management, following every procedure to ensure confident and unbiased results.

Custom Cancer Panels CORE

our Custom NGS Panel Service, you can obtain a highly customized and optimized NGS panel that precisely matches your research requirements. We look forward to working with you on your innovative discoveries, so please do not hesitate to contact us.

Reference

Pinsky PF. (2015) Principles of Cancer Screening. Surg Clin North Am. 95(5):953-66.

* For Research Use Only. Not for use in diagnostic procedures.