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ctDNA (Circulating Tumor DNA) Reference Products


CD Genomics ctDNA reference material stands as an exceptionally precise benchmark, bolstering the detection of mutations in cancer-associated cell and liquid biopsies. It encompasses a comprehensive array of 40 clinically significant mutations sourced from 28 genes spanning diverse cancer types. Our offering caters to diverse needs, with selectable allele frequency options ranging from 0%, 0.125%, 0.5%, 1%, to 2%.  

How Do You Know About ctDNA and Liquid Biopsies?

How Do You Know About ctDNA and Liquid Biopsies?

Circulating Tumor DNA (ctDNA) reference materials play a pivotal role in advancing liquid biopsy research and Next Generation Sequencing (NGS). These reference materials are not just tools, but rather catalysts in the transformative journey of cancer diagnostics and treatment. By faithfully replicating key tumor variants and mutations, they provide researchers with a crucial standardized testing resource, ensuring the precision and dependability of liquid biopsy methods.

In the realm of liquid biopsy studies, ctDNA reference materials offer a spectrum of allele frequency options, enabling researchers to recreate diverse mutation scenarios. This, in turn, aids in fine-tuning and validating assays for optimal performance. Furthermore, their versatility is exemplified by the inclusion of clinically significant variants like EGFR exon 19 deletions and SNV BRAF c.1799T>A, opening doors to a wide array of applications within liquid biopsy research.

In the context of NGS, ctDNA reference materials assume an indispensable role by facilitating the testing and validation of novel sequencing methodologies and workflows. These materials enhance the precision and efficiency of sequencing processes. Their availability empowers researchers to generate copious amounts of high-quality data in a single assay, leading to substantial cost savings for laboratories and heightened research productivity.

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Product Specifications

  • Optional Allele Frequency: 0%, 0.125%, 0.25%, 0.5%, 1%, or 2%, catering to diverse research needs.
  • Incorporates 40 Clinically Relevant Mutations: Providing a wealth of clinical insights.
  • Suitable for Cancer-Associated Cell Mutation Detection and Liquid Biopsy: Empowering cancer research and diagnostics.
  • Compatible with NGS Technology: Seamlessly integrates with cutting-edge gene sequencing techniques.
  • Analytical Sensitivity: Meets clinically relevant thresholds, aiding in setting detection sensitivity levels as low as 0.125% VAF.
  • Routine Quality Control: Ideal for daily operational controls, compliant with guidelines.

Applications

Our CD ctDNA reference material finds widespread utility in the following areas:

  • Liquid Biopsy Cancer Research: Offers reliable biomarkers for early cancer detection and disease monitoring.
  • Cancer Treatment Monitoring: Assists physicians in tracking treatment responses to optimize therapy plans.
  • Cancer Disease Recurrence Detection via Liquid Biopsy: Early detection of disease recurrence to improve treatment success.
  • Validation of Laboratory Capabilities in Labs: Used as a standard control sample for verifying laboratory analysis capabilities.
  • Positive Control for Assay Kits: Acts as a standard sample for in-kit quality control, ensuring accurate test results.
* For Research Use Only. Not for use in diagnostic procedures.

Explore Our ctDNA (Circulating Tumor DNA) Reference Products:

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Cat. No. Product Name Brief Description Inquiry Basket
CTRM001 CD ctDNA Reference Material 40 WT Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM002 CD ctDNA Reference Material 40 AF2% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM003 CD ctDNA Reference Material 40 AF1% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM004 CD ctDNA Reference Material 40 AF0.5% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM005 CD ctDNA Reference Material 40 AF0.125% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM006 CD ctDNA Mutation Mix 40 WT Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM007 CD ctDNA Mutation Mix 40 AF2% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM008 CD ctDNA Mutation Mix 40 AF1% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM009 CD ctDNA Mutation Mix 40 AF0.5% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
CTRM010 CD ctDNA Mutation Mix 40 AF0.25% Our CD ctDNA Reference Material is a highly precise reference material, supporting the detection of mutations in cancer-related cells and liquid biopsies. Includes 40 clinically relevant mutations from 28 genes associated with various cancer types. Our product provides multiple allele frequency options, including 0%, 0.125%, 0.5%, 1%, and 2%.
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