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PN207 50 reactions


Product Infomation
Product Description: The CD KRAS and BRAF RT-PCR Kit is a test product based on real-time PCR technology, which can detect KRAS exons 2, 3, and 4 and BRAF V600E mutations. KRAS and BRAF mutations affect the RAS-RAF-MEK-ERK signaling pathway to regulate cell growth, differentiation, and survival. KRAS and BRAF mutations are typical hallmarks of many types of cancer.
Features: Exon Mutation Nucleotide Change Amino Acid Change COSMIC ID
2 G12D c.35G>A Glycine (G) to Aspartic acid (D) 521
G12C c.34G>T Glycine (G) to Cysteine (C) 516
G12S c.34G>A Glycine (G) to Serine (S) 517
G12R c.34G>C Glycine (G) to Arginine (R) 518
G12A c.35G>C Glycine (G) to Alanine (A) 522
G12V c.35G>T Glycine (G) to Valine (V) 520
G13D c.38G>A Glycine (G) to Aspartic acid (D) 532
3 Q61H c.183A>C & c.183A>T Glutamine (Q) to Histidine (H) 554 & 555
Q61L c.182A>T Glutamine (Q) to Leucine (L) 553
Q61R c.182A>G Glutamine (Q) to Arginine (R) 552
4 K117N c.351A>C & c.351A>T Lysine (K) to Asparagine (N) 19940 & 28519
K117R c.350A>G Lysine (K) to Arginine (R) 1178068
K117E c.349A>G Lysine (K) to Glutamic acid (E) 1360831
A146T c.436G>A Alanine (A) to Threonine (T) 19404
A146P c.436G>C Alanine (A) to Proline (P) 19905
A146V c.437C>T Alanine (A) to Valine (V) 19900
Sequencing Platform: Real-time PCR
Storage: Store in < -20℃ freezer. Repeated thawing and freezing should be avoided.
Method: Real-time qualitative PCR
Equipment Required: Real-time PCR instrument (FAM and VIC)
Required Reagents: DNA extraction kit, pipettors and filter tips
ShippingCondition: Dry ice
* For Research Use Only. Not for use in diagnostic procedures.
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