CD Ras RT-PCR Panel

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PN208 50 reactions


Product Infomation
Product Description: The CD Ras RT-PCR Panel can be used to screen for mutations found in exons 2, 3, and 4 of the KRAS and NRAS genes. KRAS and NRAS belong to the GTPases of the RAS family and play an important role in the MAPK signaling pathway. Exon 2 (codons 12/13), exon 3 (codons 59/61), and exon 4 (codons 117/146) are found in various cancers including metastatic colorectal cancer activating mutations. It was recently found that colorectal cancer patients with KRAS and NRAS mutations respond less to anti-EGFR-targeted therapy than patients without mutations.
Features: Gene Mutation Group
KRAS G12A, G12D, G12R, G12V, G13D 1
G12C, G12S 2
Q61H, Q61L, Q61R, A59E, A59G, A59T 3
K117N, K117R, K117E 4
A146T, A146P, A146V 5
NRAS G12D, G12C, G12S, G13R, G13V, K117R 6
Q61H, Q61L, Q61K, Q61R 7
A59D, A59T, A146T 8
Sequencing Platform: Real-time PCR
Storage: Store in < -20℃ freezer. Repeated thawing and freezing should be avoided.
Method: Real-time qualitative PCR
Equipment Required: Real-time PCR instrument (FAM and VIC)
Required Reagents: DNA extraction kit, pipettors and filter tips
ShippingCondition: Dry ice
* For Research Use Only. Not for use in diagnostic procedures.
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