Details
| Product Infomation | |
|---|---|
| Product Description: | The CD c-Kit RT-PCR Kit is based on polymerase chain reaction (PCR), using allele-specific primers to identify mutations in the c-KIT gene. KIT mutations are found in approximately 5% to 30% of genital warts, mucosal melanomas, and melanomas. KIT mutations mainly occur in exon 11, followed by exons 13, 17, and 18. KIT mutation detection is valuable for melanoma treatment, and the overall response rate to imatinib in melanoma patients with KIT mutations ranges from 16% to 23%. |
| Features: | Below 5% Limit of Detection. Works with FFPE, fresh frozen and FNA. Simple setup and interpretation. Includes internal controls. Available as RUO. Mutation COSMIC ID: EX11_ p.V559D COSM1252 EX11_p.V559G COSM1253 EX11_p.V560D COSM1257 EX11_W557R COSM1216 EX17_p.D816H COSM1311 EX17_p.D816V COSM1314 EX11_p.L576P COSM1290 EX13_p.K642E COSM1304 EX9_p.Y503_F504insAY COSM12444 EX11_p.W557_E561del COSM18890 EX11_p.W557_K558del COSM12449 EX11_p.W557_V559>C COSM1233 EX11_p.W557_V559>F COSM1226 EX17_p.N822Y COSM19109 EX17_p.K818R COSM1315 EX17_p.N822H COSM1318 EX11_p.V559A COSM1255 EX11_p.W557G COSM1221 EX17_p.D820G COSM1316 EX17_p.D820Y COSM12710 EX17_p.N822K COSM1322 |
| Sequencing Platform: | Real-time PCR |
| Storage: | Store in < -20℃ freezer. Repeated thawing and freezing should be avoided. |
| Method: | Real-time qualitative PCR |
| Equipment Required: | Real-time PCR instrument (FAM, ROX, CY5 and VIC) |
| Required Reagents: | DNA extraction kit, pipettors and filter tips |
| ShippingCondition: | Dry ice |
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