Details
| Product Infomation | |
|---|---|
| Product Description: | Compared with tissue testing, liquid biopsy is convenient, rapid, immediate, inexpensive and minimally invasive, which makes it rapidly become a popular research for tumor genetic testing or even early tumor screening at present. However, due to the limitations of a series of factors such as small DNA fragments, short half-life, low abundance, gradual decrease in content during tumor treatment, normal cell DNA contamination, and different detection methods, there is no uniform standard for the accuracy of results. CD Tumor SNV Wild Type ctDNA Standard is used for the detection of complex structural variants in ctDNA samples. It can be used with Tumor Structure Variant 5% ctDNA Standard, Tumor SNV 5% ctDNA Standard, Tumor SNV 1-25% ctDNA Standard, etc. |
| Features: | Quality Standards (1)Allele Frequency (AF) Genotype is tesed by Droplet Digital PCR, the acceptance criteria as follows： AF=0%, acceptable range ≤0.1% AF <1%, acceptable error range = ±50% 1% ≤ AF <5%, acceptable error range = ±40% 5% ≤ AF < 10%, acceptable margin of error = ± 30% 10% ≤ AF, acceptable margin of error = ±20% (2)Fragment distribution is tesed by 4150 TapeStation System, the average fragment length 160bp±10%. SNV: AKT1 E17K,BRAF V600E,EGFR G719S,EGFR L858R,EGFR T790M, KRAS A146T,KRAS G12D,KRAS G13D,NRAS Q61K, PIK3CA E545K,PIK3CA H1047R. Deletion: EGFR ΔE746_A750. Insertion: EGFR A767_V769dup. Fusion: CD74(6)-ROS1(34),EML4(6)-ALK(20). CNV: MET Amplification, ERBB2 Amplification. |
| Method: | Quality Control Method: ddPCR |
| Concentration: | 20 ng/µL |
| Application: | CD Tumor SNV Wild Type ctDNA Standard is suitable for all processes of liquid biopsy: from library preparation, variant detection, to information analysis; and also for all assays: NGS sequencing, PCR detection, etc. |
| Preservation Solvent: | Tris-EDTA (10mM Tris-HCl, 1mM EDTA), pH 8.0 |
| Storage: | Store at 2-8℃, 24 months. |
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